Medical Biophysics

Christopher Macgowan PhD, University of Toronto
Associate Professor
Photo of Dr. Christopher Macgowan
Contact Info
T: (416) 813-1069
Website
Location
The Hospital for Sick Children Research Institute
Peter Giligan Centre for Research and Learning
686 Bay Street, Room 08.9714
Toronto, ON, M5G 0A4
Research Interests
Biomedical Imaging, Cardiovascular Sciences

Research/Teaching

Research Synopsis

Blood Flow Imaging with MR

My research involves the development of new magnetic resonance imaging (MRI) methods to improve the detection and evaluation of cardiovascular disease in children. In particular, I am interested in the measurement of blood flow and vascular function in congenital heart disease, and the translation of these methods into clinical practice. Previous work in my lab has involved the study of rapid (real-time) MRI measurements of blood flow, optimization of contrast-enhanced pulmonary MR angiography in children and image-processing methods to segment and classify pulmonary veins versus arteries. We have also investigated methods to assess pulmonary vascular impedance non-invasively using velocity-sensitive MR imaging, to better understand how patients with pulmonary hypertension respond to therapy.

Recent work in my lab has focused on cardiovascular physiology in the developing human fetus. Using advanced MRI methods, we are mapping the distribution of blood flow throughout the feto-placental circulation and measuring the oxygen saturation of blood supplied to the fetus. The creation of an image processing approach (metric-optimized gating) that has enabled the first dynamic MR images of the fetal heart and blood flow has been critical to this work.

Grants

External Funding Sources

  • Canadian Institutes of Health Research
  • Wellcome Trust
  • Ontario Brain Institute

Graduate Students

Chris Roy
Peter Leimbigler

Publications and Awards

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Recent Publications