Our laboratory focuses on developing new MRI technologies to revolutionize how radiation treatment is delivered in the clinic. We are developing techniques for an advanced image-guided radiotherapy platform called the MR-Linac, which integrates an external-beam linear accelerator with a diagnostic 1.5T MRI scanner. This innovative device enables delivery of external beam radiation while the patient is within the MRI environment, which provides exquisite soft-tissue contrast noninvasively at treatment time.
Treatment response monitoring. Early changes in tumour size may not stabilize until several weeks or months following treatment. Repeated MRI contrast injection also carries known risks. We are investigating MR methods which can identify changes in the tumour microenvironment. Our aim is to enable daily imaging with the MR-Linac for improved tumour delineation, and to identify early responders to therapy.
Beam-on imaging for adaptive radiotherapy. The MR-Linac provides a unique opportunity to track the motion of both tumour target and nearby organs-at-risk, whilst radiation is delivered. These tissues of interest can move significantly during a single fraction of radiation due to unavoidable physiological motions (e.g. respiratory, cardiac, swallowing, or bowel motion). We are developing methods to image the treatment volume with high spatiotemporal resolution.