The focus of our research is to characterize novel genetic risk factors and unravel mechanisms that regulate cell signaling pathways important for human cancer. A major effort of our research program is to identify novel strategies that could improve cancer therapy.
Currently ongoing projects investigate
1- BRCA1 and BRCA2 and their role in cancer
2- Signaling pathways including NOTCH, WNT and the Hippo pathways
3- CRISPR screening to identify synthetic lethal targets to kill breast, ovarian, and other tumor types
Using multidisciplinary approaches and collaborating with scientists, clinicians, pathologists and bioinformaticians, we focus on our long-term goal to contribute to better diagnosis and therapy for cancer patients.