New study from Dr. Phedias Diamandis
A new study, led by MBP researcher Dr. Phedias Diamandis titled 'Proteomic Analysis of Meningiomas Reveals Clinically-Distinct Molecular Patterns' was recently published in Neuro-Oncology, a monthly peer-reviewed medical journal covering cancer of the nervous system.
For this study, Dr. Diamandis and his team utilized liquid chromatography tandem mass spectrometry using an Orbitrap mass analyzer to quantify global protein abundances of a clinically well-annotated formalin-fixed paraffin embedded cohort of meningiomas spanning all World Health Organization (WHO) grades and various degrees of clinical aggressiveness. This proteomic study demonstrates that meningiomas of different grades and clinical parameters present distinct proteomic profiles. These proteomic variations offer potential future utility in helping better predict patient outcome and in nominating novel therapeutic targets for personalized care.