New publication from the Khokha Lab
The lab of MBP researcher Dr. Rama Khokha has released a new pubication titled "Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention"
In this EMBO Journal review, MBP PhD candidates Mathepan Mahendralingam and Pirashaanthy Tharmapalan present the concept of limiting breast cancer precursors as a risk reduction approach in high‐risk women. A wealth of information now exists for phenotypic and functional characterization of mammary stem and progenitor cells in mouse and human. Recent work has also revealed the hormonal regulation of stem/progenitor dynamics as well as intrinsic lineage distinctions between mammary epithelial populations. Leveraging these insights, molecular marker‐guided chemoprevention is an achievable reality.