New Publication from Dr. Trevor Pugh

Jul 7, 2021

A photo of Dr. Trevor PughDr. Trevor Pugh

MBP researcher Dr. Trevor Pugh has published a new Nature Communications article entitled ‘Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape.’ Co-authors on the article include MBP scientist Dr. Fei-Fei Liu.

Article Abstract
Interplay between EBV infection and acquired genetic alterations during nasopharyngeal carcinoma (NPC) development remains vague. Here we report a comprehensive genomic analysis of 70 NPCs, combining whole-genome sequencing (WGS) of microdissected tumor cells with EBV oncogene expression to reveal multiple aspects of cellular-viral co-operation in tumorigenesis. Genomic aberrations along with EBV-encoded LMP1 expression underpin constitutive NF-κB activation in 90% of NPCs. A similar spectrum of somatic aberrations and viral gene expression undermine innate immunity in 79% of cases and adaptive immunity in 47% of cases; mechanisms by which NPC may evade immune surveillance despite its pro-inflammatory phenotype. Additionally, genomic changes impairing TGFBR2 promote oncogenesis and stabilize EBV infection in tumor cells. Fine-mapping of CDKN2A/CDKN2B deletion breakpoints reveals homozygous MTAP deletions in 32-34% of NPCs that confer marked sensitivity to MAT2A inhibition. Our work concludes that NPC is a homogeneously NF-κB-driven and immune-protected, yet potentially druggable, cancer.

View the article on the Nature Communications website.

May 5 – Sep 1
National Chats for Change: Systems Thinking for Transformational Change
EDI Seminar/Workshop | 12:00pm–1:00pm
Jun 28 – Aug 30
Careers by Design: Building a Professional Development Blueprint workshops
EDI Seminar/Workshop | 4:00pm–5:00pm
Aug 9 New Investigator Seminar - Dr. Jan Seuntjens
New Investigator Seminar | 10:00am–11:00am
Sep
27 – 28
2020 Virtual Geneva Park Retreat
Student Event | All day