At a Glance
- We aim to identify signalling mechanisms that support cancer cell adaptation and survival in the tumor microenvironment.
- Areas of focus include deregulation of cancer metabolism, maintenance of redox homeostasis and mechanisms that support protein secretion.
- We seek to combine molecular targeting with radiotherapy to enhance treatment efficacy.
Dr. Koritzinsky is a Scientist at the Princess Margaret Cancer Centre in Toronto. She is Associate Professor and Director of Research at the Department of Radiation Oncology, and Full member of the Institute of Medical Science, University of Toronto.
Research in Dr. Koritzinsky's laboratory is focused on vulnerabilities in cancer that emerge as a consequence of the tumor microenvironment. Tumor hypoxia confers poor patient prognosis due to resistance to radiation and chemotherapy, and stimulation of a more aggressive phenotype. The aim of Dr. Koritzinsky’s research program is to increase our understanding of molecular and cellular responses to hypoxia, with the ultimate goal of targeting these responses to improve cancer treatment efficacy, mitigate cancer aggressiveness and improve patient outcomes. Research is focused on determining how cancer cells regulate metabolism, redox homeostasis and secretion capacity.
Dr. Koritzinsky is a recipient of the ESTRO-Juliana Denekamp research award, the Terry Fox Research Institute New Investigator award, the Radiation Research Society Michael Fry award and the Department of Radiation Oncology Excellence in Research Leadership Award.