Molecular Engineering and the Development of Targeted Biological Therapies
Our laboratory is interested in developing both in vivo imaging modalities and targeted therapies directed at inflammatory diseases and cancer (breast, colon, prostate, ovarian, lung, and pancreas). Our research program is a fine balance of both basic and applied research projects aimed at understanding how peptides, proteins and oligonucleotide templates work and how they can be engineered or utilized in developing directed therapies against tumor cells (either through the design of cancer vaccines, DNAaptamers and immune checkpoint protein biologics.) or as novel anti-inflammatory agents.
The spectrum of approaches taken by our group to address our design and discovery programs ranges from protein engineering, combinatorial protein or DNA library design/screening, cell biology/microscopy techniques to yeast genetics and mouse models.
Because of the broad nature of our molecular engineering efforts, projects in our laboratory are usually tailored to a student’s expectations and aptitudes.