Blood Flow Imaging with MR

My research interests centre on cardiovascular disease and, in particular, blood flow and its relation to vascular development and function. The goals of my laboratory are focused on the magnetic resonance (MR) assessment of blood flow:

• To improve our understanding of cardiovascular function and vascular biology through the development of MR measurements of blood flow and anatomy
• To create an intuitive user interface to the MR scanner that provides real-time control of the acquisition, processing, and visualization of cardiovascular physiology
• To translate these methods into the clinic to investigate pathology, such as pulmonary hypertension and congenital heart disease.

For further details please see: http://www.sickkids.ca/AboutSickKids/Directory/People/M/christopher-macgowan-staff-profile.html

Graduate Students:

• Sina Fazel-Pour
• Michael Jansz
• Peter Leimbigler
• Christopher Wernik

Selected References:

Link to Pubmed Publications

van Amerom JFP, Wu S-P, Vidarsson L, Tessler R, Belik J, Macgowan CK.
Comparison Between Dynamic Contrast-Enhanced MR Perfusion and Phase-Contrast MR Flow Measurement in the Lungs
Magn. Reson. Med.  61(5), 1249-1254 (2009)

van Amerom JFP, Kellenberger CJ, Yoo S-J, Macgowan CK.
Automated Measurement and Classification of Pulmonary Blood-Flow Velocity Patterns Using Phase-Contrast MRI and Correlation Analysis
Magn. Reson. Imaging.  27(1), 38-47 (2009)

Tessler R, Wu S-P, Fiori R, Macgowan CK, Belik J.
Sildenafil Acutely Reverses the Hypoxic Pulmonary Vasoconstriction Response of the Newborn Pig
Pediatr. Res.  64(3), 251-255 (2008)

Macgowan CK, Al-Kwifi O, Varodayan F, Yoo S-J, Wright GA, Kellenberger CJ.
Optimization of 3D Contrast-Enhanced Pulmonary MRA in Paediatric Patients with Cardiovascular Disease
Magn. Reson. Med.: 54:207–212 (2005)

Macgowan CK, Kellenberger CJ, Detsky JS, Roman K, Yoo S-J.
Real-Time Fourier Velocity Encoding: An In-Vivo Evaluation
J. Magn. Reson. Imag.  21, 297–304 (2005)