Christine Démoré

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Assistant Professor

PhD, Queen's University, Kingston

Sunnybrook Health Sciences Centre
2075 Bayview Avenue, Room S654
Toronto, Ontario M4N 3M5

Phone: (416) 480-6045
Email Dr. Christine Démoré

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Short Bio:

Christine Démoré completed her BSc Engineering Physics in 2000 and PhD Physics in 2006, both at Queen’s University, Kingston, Canada, before moving to Scotland. From 2007 to 2015 she was based at the Institute for Medical Science and Technology, University of Dundee, and at the School of Engineering, University of Glasgow in 2016. Dr. Démoré is now a Scientist at Sunnybrook Research Institute, and Assistant Professor in the Department of Medical Biophysics, University of Toronto. From 2013 to 2016 she held the Royal Society of Edinburgh / Caledonian Research Fund Biomedical Personal Research Fellowship, and she was awarded the IEEE Ultrasonics Young Investigator Award in 2015.

 

Research Overview:

My research involves the development and application of ultrasonic devices and systems tailored for emerging biomedical applications. My work includes developing new ultrasound probes for a range of medical imaging applications, and creating devices for acoustic tweezing with applications in biosciences research.

The primary focus of my research is the development of miniature, high resolution ultrasound for clinical imaging. The ultrasound scanners commonly used in most clinical situations can provide images with resolution on the order of 1 mm. While this is useful for many clinical applications, there are many clinical and pre-clinical applications that can benefit from improved image resolution. Micro-ultrasound, with resolution in the range of 10 – 100 μm, is needed to resolve the fine structure of tissues, requiring in turn new ultrasound probes, or transducer arrays, capable of imaging with these resolutions to enable the new clinical applications.

Since both the probe dimensions and image resolution scale with the imaging wavelength (and conversely with operating frequency), miniaturised probes can to be developed. This introduces many challenges in fabricating new devices, but also creates opportunities for integrating miniature probes in endoscopes or other interventional tools like biopsy needles, that can be used for diagnosis and guiding a range of clinical procedures. Examples are the design of new probes integrated into biopsy needles optimised for guiding procedures in neurosurgery, or integrated into a swallowable pill for investigating gastrointestinal diseases. Alongside the development of new devices, my group is exploring the clinical and pre-clinical applications of micro-ultrasound imaging.

I have also developed transducer arrays for biosciences research applications, creating arrays with independently controlled elements that generate reconfigurable ultrasound fields for trapping and moving particles and cells. I have also used reconfigurable arrays to produce complex ultrasound fields, demonstrating real-world versions of science fiction concepts such as “Sonic Screwdrivers” and “Tractor Beams”.

 

List of Key Publications:

Link to Pubmed Publications

  • Y. Jiang, Z. Qiu, R. McPhillips, C. Meggs, S.O. Mahboob, H. Wang, R. Duncan, D. Rodriguez Sanmartin, Y. Zhang, G. Schiavone, R. Eisma, M.P.Y. Desmulliez, S. Eljamel, S. Cochran, T.W. Button, and C.E.M. Démoré “Dual Orientation 16 MHz Single Element Ultrasound Needle Transducers for Image-Guided Neurosurgical Intervention,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Vol. 63, p. 233-244, Feb. 2016.

  • Yongqiang Qiu, James V. Gigliotti, Margeaux Wallace, Flavio Griggio, Christine E. M. Demore, Sandy Cochran and Susan Trolier-McKinstry, "Piezoelectric Micromachined Ultrasound Transducer (PMUT) Arrays for Integrated Sensing, Actuation and Imaging,” Sensors, vol. 15, 8020-8041, April 2015.

  • C.E.M. Demore, P. Dahl, Z. Yang, P. Glynne-Jones, A. Melzer, S. Cochran, M.P. MacDonald, and G.C. Spalding, “Acoustic Tractor Beam,” Physical Review Letters, vol. 112, 174302, 2014.

  • C.E.M. Demore, Z. Yang, A. Volovick, S. Cochran, M.P. MacDonald, and G.C. Spalding, “Mechanical evidence of the orbital angular momentum to energy ratio of helical beams,” Physical Review Letters, Vol. 108, 194301, May 2012.

  • C.E.M. Demore, P. Glynne-Jones, C. Ye, Y. Qiu, S. Cochran, and M. Hill, “Array Controlled Ultrasonic Manipulation of Particles in Planar Acoustic Resonator,” IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Vol 59, No. 6, pp. 1258-1266, June 2012.

  • C.E.M Démoré, A.W. Joyce, K. Wall, G.R. Lockwood, “Real-time Volume Imaging Using a Crossed Electrode Array”, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control, Vol. 56, No. 6, pp. 1252-1261, June 2009.

 

Graduate Students: