New Publication from Dr. Mohammad Mazhab-Jafari

MBP researcher Dr. Mohammad Mazhab-Jafari and fellow research collaborators have recently published a new Nature Communications Biology article entitled 'Steric Occlusion Regulates Proximal Interactions of Acyl Carrier Protein Domain in Fungal Fatty Acid Synthase'.

Article Abstract
"The acyl carrier protein (ACP) domain shuttles substrates and reaction intermediates in type I fungal fatty acid synthases via transient protein-protein interactions. Here, using electron cryo-microscopy (cryoEM), we report the structure of a fungal FAS stalled at the dehydration reaction, which precedes the final enoyl reduction in the fatty acid biosynthesis cycle. This conformation revealed multiple contact sites between ACP and the dehydratase (DH) and enoyl reductase (ER) domains that occluded the ACP binding to the adjacent ER domain. Our data suggests a minimal path from the DH to the ER reaction site that requires minute changes in the coordinates of the structured N- and C- termini of the ACP domain."

Learn More
View the article on the Communications Biology website.