Mr. Michael HaThesis Title: Development of Mouse Models of Measles Virus Infection: Role of the Innate Immune System The following will comprise Mr. Ha's examining committee: Drs. Martha Brown (Molecular Genetics), Fei-Fei Liu (Supervisory Committee Member), Jeff Medin (Supervisory Committee Member), Gil Prive (MBP), and Chris Richardson (Supervisor). Dr. Pierre Talbot (Institut National de la Recherche Scientifique) is the external appraiser. Mr. Jeremy HoisakThesis Title: A Measure of Voxel Similarity
for Improving the Image-Based Quantification of Tissue Structure and Function The following will comprise Mr. Hoisak's examining committee: Drs. Robert Bristow (Supervisory Committee Member), Curtis Caldwell (MBP), Tom Chau (IBBME), David Jaffray (Supervisor), Robert Jeraj (University of Wisconsin - Madison), and Anne Martel (Supervisory Committee Member). 2011
Mr. Brige ChughThesis Title: Imaging Microvascular Changes
Associated with Neurological Diseases. The following will comprise his examining committee: Drs. D. Alsop (Harvard Medical School), S. Graham (Supervisory Committee Member), K. Gordon (SGS Chair), R. Harrison (Supervisory Committee Member), M. Henkelman (Supervisory Committee Member), J. McLaurin (LMP), J. Sled (Supervisor) and M. Yaffe (MBP). Ms. Christine ChioThesis Title: TRADD mediates inflammatory responses in the cytoplasm and tumor suppression in the nucleus The following will comprise Ms. Chio's examining committee: Drs. Sam Aparicio (University of British Columbia), James Dennis (Molecular Genetics), Rama Khokha (Supervisory Committee Member), Tak Mak (Supervisor), Ben Neel (Supervisory Committee Member) and Hitoshi Okada (MBP). Mr. Mathieu RoyThesis Title: Quantitative Evaluation of Semiconductor Nanocrystals as Contrast Agents for Fluorescence Molecular Imaging The following will comprise Mr. Roy's examining committee: Drs. Kristy Brock (MBP), Warren Chan (Supervisory Committee Member), Thomas Foster (University of Rochester), Ulrich Krull (Chemistry), Anne Martel (Supervisory Committee Member), and Ming Tsao (Supervisory Committee Member). Dr. Brian Wilson (Supervisor) is a non-voting member Ms. Ling LingThesis Title: Role of the phosphatidylinositol 3' kinase pathway in stem cell self-renewal and growth The following will comprise Ms. Ling's examining committee: Drs. Robert Casper (Inst of Medical Sciences), Pamela Hoodless (University of British Columbia), Chi-Chung Hui (Supervisory Committee Member), Rama Khokha (MBP), Vuk Stambolic (Supervisory Committee Member), and Jim Woodgett (Supervisor). Nataliya NadyThesis Title: Reading the Histone Code: Methyl Mark Recognition By MBT and Royal Family Proteins The following will comprise Ms. Nady's examining committee: Drs. Cheryl Arrowsmith (Supervisor), Avi Chakrabartty (MBP), Peter Cheung (Supervisory Committee Member), Peter McPherson (Pharmacology & Toxicology), Gil Privé (Supervisory Committee Member), and Judd Rice (University of Southern California). Mr. Mark JarviThesis Title: Evaluation of Photophysical Methods for Photodynamic Therapy Dosimetry The following will comprise his examining committee: Drs. Virginijus Barzda (Dept of Chemical and Physical Sciences), Richard Hill (Supervisory Committee Member), David Jaffray (Supervisory Committee Member), Irene Kochevar (Harvard Medical School), Alex Vitkin (MBP), and Brian Wilson (Supervisor). Dr. Michael Patterson (Supervisory Committee Member) is a non-voting member. Mr. Sameer AgnihotriThesis Title: GATA4 Represses Formation of Glioblastoma Multiforme. The following will comprise his examining committee: Drs. Jane McGlade (MBP), Andras Nagy (Supervisory Committee Member), David Rowitch (University of California, San Francisco), Vuk Stambolic (Supervisory Committee Member), William Stanford (Supervisory Committee Member), and Michael Taylor (LMP). Dr. Dwayne Barber (MBP) is a non-voting member. Ms. Cynthia SolekThesis Title: A Gene Regulatory Network for the Specification of Immunocytes in an Invertebrate Model System. The following will comprise her examining committee: Drs. M. Anderson (Immunology), Y. Ben-David (Supervisory Committee Member), J. Coffman (University of Maine), M. Puri (Supervisory Committee Member), J. Rast (Supervisor) and R. Wells (MBP). Ms. Megan NellesThesis Title: Characterization of an IL-12-driven anticancer response, and the CD4+ CTL population incited, in a murine model of leukaemia The following will comprise Ms. Nelles's examining committee: Drs. Dwayne Barber (Supervisory Committee Member), Eleanor Fish (Immunology), Mark Minden (MBP), Brad Nelson (University of British Columbia), Linda Penn (Supervisory Committee Member), and Robert Rottapel (Supervisory Committee Member). Dr. Chris Paige (Supervisor) is a non-voting member. Ms. Jelena TomicThesis Title: Abberations in Cytokine Signalling in Leukemia: Variations in Phosphorylation and O-GlcNAcylation The following will comprise her examining committee: Drs. M. Anderson (Immunology), J. Booth (Supervisory Committee Member), D. Dumont (Supervisory Committee Member), S. Gibson (University of Manitoba), D. Spaner (Supervisor) and R. Wells (MBP). Mr. Luc CharronThesis Title: Integrated Microfluidic Optical Manipulation Technique: Towards High Throughput Single Cell Analysis
The following will comprise his examining committee: Drs. Avi Chakrabartty (Supervisory Committee Member), Axel Guenther (Mechanical & Industrial Engineering), Lothar Lilge (Supervisor), Richard Oleschuk (Queen’s University), Bojana Stefanovic (MBP), and Aaron Wheeler (Supervisory Committee Member). Mr. Anton NeschadimThesis Title: Development of Novel Cell Fate Control Gene Therapy for Applications in Cancer and Immune Disorders The following will comprise Mr. Neschadim's examining committee: Drs. Robert Bristow (Supervisory Committee Member), John DiPersio (Washington University School of Medicine), Cynthia Guidos (Immunology, U of T), Thomas Hudson (MBP), Jeffrey Medin (Supervisor), and Aaron Schimmer (Supervisory Committee Member). Mr. Aditya MurthyThesis Title: Regulation of metalloproteinase-dependent
ectodomain shedding in cytokine biology and inflammation
The following will comprise his examining committee: Drs. Razq Hakem (Supervisory Committee Member), Rama Khokha (Supervisor), Freddy Radtke (Ecole Polytechnique Federale de Lausanne), Robert Rottapel (Supervisory Committee Member), James Woodgett (MBP), and Juan Carlos Zúñiga-Pflücker (Immunology, U of T). Ms. Patricia Wang PanThesis Title: Structural Basis for Enzyme Promiscuity and Specificity - Insights from human cytosolic Sulfotrousterases (SULTs) and Sirtuins (SIRTs) families
The following will comprise her examining committee: Drs. Cheryl Arrowsmith (Supervisory Committee Member), Peter Cheung (MBP), Aled Edwards (Supervisor), Denis Grant (Supervisory Committee Member), Hee-Won Park (Pharmacology), and Anthony Sauve (Weill Medical College of Cornell University). Mr. Linyuan WangThesis Title: The role of PTEN in pancreatic beta cells and insulin promoter-expressing neurons in modulating glucose metabolism and energy homeostasis The following will comprise his examining committee: Drs. Adria Giacca (Physiology, U of T), Armen Manoukian (Supervisory Committee Member), Dominic Ng (Supervisory Committee Member), Silvana Obici (University of Cincinnati), Minna Woo (Supervisor), Eldad Zacksenhaus (MBP), and SGS Chair (TBA). Mr. Reza Beheshti ZavarehThesis Title: Investigation of the Effects of Inhibiting N-Glycosylation in Cancer
The following will comprise his examining committee: Drs. Sylvia L. Asa (LMP), Michael Demetriou (University of California, Irvine), James W. Dennis (Supervisory Committee Member), David R. Rose (Supervisory Committee Member), Aaron Schimmer (Supervisor), Eldad Zacksenhaus (MBP), and SGS Chair (TBA). Mr. Konstantin PopovicThesis Title: Structural and Functional Studies of the Human Saposin Proteins The following will comprise his examining committee: Drs. John Baenziger (University of Ottawa), Avi Chakrabartty (Supervisory Committee Member), Charles Deber (Biochemistry), Jean Gariépy (MBP), David Irwin (SGS Chair), Gil Privé (Supervisor), Don Mahuran (Supervisory Committee Member. Mr. David McIlwainThesis Title: Functional analysis of the pseudo protease iRhom2 and nonsense-mediated RNA decay factor Smg1 using gene deficient mice
The following will comprise his examining committee: Mr. McIlwain's examining committee: Drs. Aled Edwards (Supervisory Committee Member), Paul Fraser (Supervisory Committee Member), Douglas Green (St. Jude Children Research Hospital), Rupert Kaul (SGS Chair), Angus McQuibbon (Supervisory Committee Member), Anurag Tandon (IMS), Minna Woo (MBP). Dr. Tak Mak (Supervisor) is a non-voting member. Ms. Monique RennieThesis Title: Development of the Fetoplacental Vascular Tree in Mice During Normal and Growth Restricted Pregnancies. The following will comprise her examining committee: Dr. S. Lee Adamson (Supervisory Committee Member), Dr. Mark Henkelman (Supervisory Committee Member), Dr. Andrea Jurisicova (Physiology), Dr. Chris Macgowan (MBP), Dr. Yoel Sadovsky (University of Pittsburgh), Dr. John G. Sled (Supervisor), Dr. David Steinman (Supervisory Committee Member). Mr. Jack LiaoThesis Title: Structural and Biophysical Characterization of Tumor Suppressor p53-Interacting Proteins The following will comprise his examining committee: Drs. M. R. Adcock (SGS Chair), R. Bristow (Supervisory Committee Member), A. Davidson (Biochemistry), J. Greenblatt (Supervisory Committee Member), R. Hakem (Supervisory Committee Member), R. Kriwacki (St. Jude Children's Research Hospital), and G. Privé (MBP). Dr. C. Arrowsmith (Supervisor) is a non-voting member. Mr. Aaron GajadharThesis Title: In situ proximity ligation-based analysis reveals aberrant dimerization and activation of EGFRs prevalent in glioblastoma multiforme The following will comprise his examining committee: Drs. A. Chakrabartty (Supervisory Committee Member), A. Guha (Supervisor), F. Furnari (University of California-San Diego School of Medicine), A. Huang (LMP), J. McGlade (Supervisory Committee Member), M. Tsao (MBP), and SGS Chair (TBA). Ms. Krupa PatelThesis Title: Distribution of anti-cancer drugs within solid tumours and normal tissues and its potential for modification to improve therapeutic index. The following will comprise his examining committee: Drs. D. Goertz (MBP), D. Hedley (Supervisory Committee Member), L. Lilge (Supervisory Committee Member), R. Reilly (Leslie Dan Faculty of Pharmacy, U of T), Y. Rustum (Roswell Park Cancer Institute), I. Tannock (Supervisor), and Dr. C. Pace-Asciak (SGS Chair). Mr. General LeungThesis Title: Magnetic Resonance Imaging Detected Intraplaque Haemorrhage as an Endogenous Imaging Biomarker and Therapeutic Target. The following will comprise her examining committee: Drs. D. Goertz (MBP), A. Martel (Supervisory Committee Member), A. Moody (Supervisor), D. Steinman (IBBME), G. Wright (Supervisory Committee Member), C. Yuan (University of Washington) and SGS Chair (TBA). Mr. John HudsonThesis Title: Quantification of Blood Flow Using Ultrasound Contrast Agents. The following will comprise his examining committee: Drs. M. Averkiou (University of Cyprus), P. Burns (Supervisor), R. Cobbold (IBBME), L. Osborne (SGS Chair), A. Martel (MBP), A. Vitkin (Supervisory Committee Member) and G. Wright (Supervisory Committee Member). Mr. Michael WoodThesis Title: Development and Use of Polarized Light Methods to Assess Structure and Composition of Biological Tissue. The following will comprise his examining committee: Drs. A. Dick (Medical Sciences, U of T), S. Jacques (Oregon Health and Science University), L. Lilge (Supervisory Committee Member), D. Plewes (Supervisory Committee Member), D. van der Kooy (MBP), A. Vitkin (Supervisor), and M. McAndrews (SGS Chair). Mr. Max KotlyarThesis Title: Predication of Protein-Protein Interactions and Essential Genes Through Data Integration The following will comprise his examining committee: Drs. G. Bader (Banting and Best Dept of Medical Research, U of T), I. Jurisica (Supervisor), M. Park (McGill University), L. Penn (MBP), D. Trictler (Supervisory Committee Member), M.S. Tsao (Supervisory Committee Member), and J. Yeomans (SGS Chair). 2010
Mr. Mehran HaeriThesis Title: Genetic and Microenivronmental Effects on Friend Murine Leukemia Virus-Induced Erythroleukemia. The following will comprise his examining committee: Y. Ben-David (Supervisor), D. Spaner (Supervisory Committee Member), S. Berger (Supervisory Committee Member), J. Lee (University of Ottawa), J. Rast (MBP), M. Hough (LMP) and B. Yang (SGS Chair). Mr. Mathieu BurtnykThesis Title: Conformal heating of the prostate for the treatment of localized cancer using MRI-guided transurethral ultrasound The following will comprise his examining committee: M. Bronskill (Supervisor), D. Plewes (Supervisory Committee Member), K. Hynynen (Supervisory Committee Member), R. Chopra (Supervisory Committee Member), J. Stafford (University of Texas), D. Goertz (MBP), M. Haider (IMS), and Rick Glazier (SGS Chair). Mr. Amandeep ThindThesis Title: Novel Uses for Ultrasound as Both an Imaging and Therapeutic Tool in the Characterization and Percutaneous Revascularization of Chronic Total Occlusion. The following will comprise his examining committee: F. Stuart Foster (Supervisor), G. Wright (Supervisory Committee Member), B. Strauss (Supervisory Committee Member), A. Vitkin (Supervisory Committee Member), J. Hossack (University of Virginia), H. Leong-Poi (Medicine), A. Seth (LMP) and SGS Chair (TBA). Ms. Laura Vecchiarelli-FedericoThesis Title: Elucidating the Role of Fli-I in Normal Development and Malignant Transformation. The following will comprise her examining committee: Drs. B. Barbeau (University du Quebec à Montreal), Y. Ben-David (Supervisor), D. Dumont (Supervisory Committee Member), J. Filmus (MBP), M. Hough (LMP), M. Puri (Supervisory Committee Member), J.C. Zúñiga-Pflücker (Supervisory Committee Member), and C. Whyne (SGS Chair). Mr. Joseph ProsperThesis Title: Characterization of CD109 The following will comprise his examining committee: Drs. D. Barber (MBP), E. Conway (University of British Columbia), N. Iscove (Supervisory Committee Member), M Rand (Biochemistry, U of T), R. Rottapel (Supervisory Committee Member), E. Yeo (Supervisory Committee Member), and SGS Chair (TBA). Dr. A. Schuh (Supervisor) is a non-voting member. Mr. Adam ShlienThesis Title: Genomic DNA Copy Number Variations and Cancer: Studies of Li-Fraumeni Syndrome and its Variants The following will comprise his examining committee: Drs. D. Hogg (Supervisory Committee Member), R. Jankov (SGS Chair), A. Huang (LMP, U of T), C. Lee (Harvard Medical School), S. Meyn (Supervisory Committee Member), B. Raught (MBP), and J. Squire (Supervisory Committee Member). Dr. D. Malkin (Supervisor) is a non-voting member. Ms. Mamta KhuranaThesis Title: Two-photon Excitation Photodynamic Therapy for Localized Blood Vessel Targeting The following will comprise her examining committee: Drs. C. Allen (Committee Member), D. Dumont (Committee Member), T. Foster (University of Rochester), B. Wilson (Supervisor), B. Wouters (MBP), C. Yip (IBBME, UofT) and SGS Chair (TBA). Mr. Norman ChanThesis Title: Hypoxia Suppresses DNA Repair: Implications for Cancer Progression and Treatment.
The following will comprise his examining committee: Drs. R. Bristow (Supervisor), D. Durocher (Med Gen, UofT), R. Hakem (Committee member), R. Hill (Committee member), F-F. Liu (MBP), M. Weinfeld (University of Alberta), and SGS Chair (TBA). Mr. Adrian MariampillaiThesis Title: Hypoxia Suppresses DNA Repair:
Implications for Cancer Progression and Treatment. The following will comprise his examining committee: Drs. R. Bristow (Supervisor), D. Durocher (Med Gen, UofT), R. Hakem (Committee member), R. Hill (Committee member), F-F. Liu (MBP), M. Weinfeld (University of Alberta), and SGS Chair (TBA). Mr. Anthony KimThesis Title: Quantitative and depth-resolved
fluorescence guidance for the resection of glioma. The following will comprise his examining committee: Drs. P. Herman (Elect & Comp Eng, UofT), L. Lilge (Committee member), F-F. Liu (MBP), A. Martel (Committee member), M-A. Mycek (Dept of Biomed Eng., Univ of Michigan), B. Wilson (Supervisor), and SGS Chair, TBA. Ms. Victoria NguyenThesis Title: Comparative Approaches to Characterization of Lymphatic Endothelial Cells as Phenotypically Distinct from Blood Endothelial Cells. The following will comprise her examining committee: Drs. D. Barber (Supervisory Committee Member), M. Bendeck (LMP), D. Dumont (Supervisor), T. Haas (York University), M. Hough (SGS Chair), M. Moran (Supervisory Committee Member) and R. Wells (MBP). Ms. Larissa LiontosThesis Title: The Role of the Src-like Adaptor
Proteins, SLAP and SLAP-2 in Dendritic Cell development and signaling. The following will comprise her examining committee: Drs. D. Barber (Committee member), C. Carter-Su (University of Michigan), S. Egan (Mol Gen, UofT), J. McGlade (Supervisor), R. Rottapel (Committee member), V. Stambolic (MBP) and SGS Chair, TBA. Ms. Mihaela PopThesis Title: 3D Magnetic Resonance Image-Based Cardiac Computer Models of Electrophysiology. The following will comprise her examining committee: Drs. L. Axel (New York University), M. Bronskill (Supervisory Committee Member), M. Kolios (Supervisory Committee Member), A. Martel (MBP), A. Nachman (Mathematics), M. Wojtowicz (SGS Chair) and G. Wright (Supervisor). Ms. Kelly JacksThesis Title: Identification and characterization
of a novel CK2-MSK2 interaction in the UV response The following will comprise her examining committee: Drs. P. Cheung (MBP), A-C. Gingras (Mol Gen), A. Koch (Supervisor), D. Litchfield (Univ of Western Ontario), J. McGlade (committee member), V. Stambolic (committee member) and SGS Chair (TBA). Ms. Tamara Maiuri (Landry)Thesis Title: Specificity in P13KB/Akt-PTEN
Signaling: Subcellular Locus-Specific Functions of Pathway Targets The following will comprise her examining committee: Drs. D. Barber (Supervisory Committee Member), P.Cheung (MBP), J. McGlade (Supervisory Committee member), W. Muller (McGill University), D. Rotin (Biochemistry, U of T), V. Stambolic (Supervisor), and SGS Chair (TBA) Mr. Anthony MutsaersThesis Title: Biomarker and Therapeutic Studies
of Antibodies and Small Molecules and Target EGFR. The following will comprise his examining committee: Drs. C. Bear (SGS Chair), Y. Ben-David (MBP), A. Guha, R. Kerbel (Supervisor), M. Pollak (McGill University), A. Seth (Dept. of Laboratory Medicine and Pathobiology) and I. Tannock (Supervisory Committee Member). Ms. Emma ItoThesis Title: High-throughput screening for
novel anti-cancer radiosensitizers for head and neck cancer. The following will comprise her examining committee: Drs. L. Ailles (MBP), M. Gleave (University of British Columbia), M. Irwin (IMS), A. Koch (Supervisory Committee member), F-F. Liu (Supervisor), A. Schimmer (Supervisory Committee member), and SGS Chair (TBA). Mr. Michael TaboskiThesis Title:
The role of telomerase reverse transcriptase in tumorigenesis. The following will comprise his examining committee: Drs. Drs. S. Benchimol (committee member), C. Counter (Duke University Medical Center), C. Guidos (Immunology), L. Harrington (Supervisor), S. Meyn (committee member), H. Vaziri (MBP) and SGS (TBA). Ms. Ira KimThesis Title: The Role of PIDD in Cell Death and Antiviral Innate Immunity. The following will comprise her examining committee: Drs. R. Hakem (Supervisory Committee member), S. Lesage (University of Montreal), M. Minden (MBP), J. McGlade (Supervisory Committee member), P. Ohashi (Supervisor), T. Watts (Immunology, UofT) and P. Pennefather (SGS Chair). Ms. Andrea FungThesis Title: The effect of molecular
targeted agents used in combination with chemotherapy to inhibit the repopulation
of tumour cells and xenografts The following will comprise her examining committee: Drs. C. Allen (Pharmacy), C. Koch (University of Pennsylvania), F-F Liu (Supervisory Committee member), R. Kerbel (MBP), I. Tannock (Supervisor), M. Tsao (Supervisory Committee member) and SGS Chair(TBA). Ms. Amy LinThesis Title: Investigations into the
Biological Roles of the E3 Ligase Ariadne 2/TRIAD 1 The following will comprise her examining committee: Drs. T. Mak (Supervisor), M. Minden (Supervisory Committee Member), V. Stambolic (Supervisory Committee Member), J. Woodgett (Supervisory Committee Member), J. Dennis (Molecular and Medical Genetics), A. Ma (University of California), A. Manoukian (MBP), and SGS Chair (TBA). Ms. Larissa MonizThesis Title: Characterization of NimA-related
kinase 10 (NEK10): a role in checkpoint control The following will comprise her examining committee: Drs. V. Stambolic (Supervisor), D. Durocher (Supervisory Committee Member), J. Woodgett (Supervisory Committee Member), M. Moran (Molecular and Medical Genetics), J. McGlade (MBP), T. Sturgill (University of Virginia, and SGS Chair (TBA). Ms. Lyann SimThesis Title: Structural and inhibition studies
of human intestinal glucosidases The following will comprise her examining committee: Drs. D. Rose (Supervisor), P.L. Howell (Supervisory Committee Member), G. Prive (Supervisory Committee Member), J. Dennis (Molecular Genetics), M. Rauth (MBP), A. J. Clarke (University of Guelph), and SGS Chair (TBA). Ms. Ying-Ju JangThesis Title: Characterization of the
Physiological Role of PDZ-RhoGEF in Drosophila and Mice. The following will comprise her examining committee: Drs. T. Mak (Supervisor), S. Benchimol (Supervisory Committee Member), J. Woodgett (Supervisory Committee Member), S. Egan (Molecular Genetics), M. Ikura (MBP, R. Parsons (Columbia University), and SGS Chair (TBA). Ms. Cheryl WoltingThesis Title: Development and Implementation
of Gene Ontology Cluster Analysis of Protein Array Data The following will comprise her examining committee: Drs. J. McGlade (Supervisor), G. Bader (Supervisor Committee Member), J. Woodgett (Supervisory Committee Member), A. Emili (Molecular Genetics, UofT), D. Barber (MBP), S. Robbins (University of Calgary) and S. Cordes (SGS Chair). Mr. David SealeyThesis Title: Regulation of telomerase by DNA and protein interactions The following will comprise his examining committee: Drs. S. Benchimol (Supervisory Committee Member), R. Bristow (Supervisory Committee Member), B. Derry (Molecular Genetics), M. Gauthier (MBP), L. Harrington (Supervisor), R. Wellinger (Universite de Sherbrooke) and L. Pelletier (SGS Chair). 2009
Ms. Kimberly LauThesis Title: Function and regulation of the cell fate determinant Numb in polarized epithelial cells The following will comprise her examining committee: Drs. J. McGlade (Supervisor), V. Stambolic (Supervisory Committee Member), S. Egan (Supervisory Committee Member), R. Khokha (MBP), D. Rotin (Biochemistry, UofT), B. Margolis (U of Michigan), and SGS Chair (TBA). Mr. James ClendeningThesis Title: Molecular Rationale & determinants of sensitivity for statin-induced apoptosis of human tumour cells The following will comprise his examining committee: Drs. L. Penn (Supervisor), M. Minden (Supervisory Commitee Member), T. Mak (MBP), S. Berger (Immunology, UofT), F. Appelbaum (Fred Hutchinson Cancer Rsch Ctr), and SGS Chair (TBA). Mr. Jacob LevmanThesis Title: On the Pattern Recognition Applied to the Computer-Aided Detection of Breast Cancer from Dynamic Contrast-Enhanced Magnetic Resonance Breast Images. The following will comprise his examining committee: Drs. T. Chau (IBBME), A. Martel (Supervisor), R. Nishikawa (University of Chicago), D. Plewes (Supervisory Committee Member), G. Stanisz (Supervisory Committee Member), M. Yaffe (MBP) and A. Ravindran (SGS Chair). Ms. Shahnaz Al RashidThesis Title: The role of the p53 tumour suppressor protein and sensing of ionizing radiation-induced DNA double-strand breaks The following will comprise her examining committee: Drs. C. Arrowsmith (Supervisory Committee Member), S. Benchimol (Supervisory Committee Member), R. Bristow (Supervisor, Non-voting member), M. Gauthier (MBP), M. Ljungman (University of Michigan), L. Lilge (Supervisory Committee Member), and P. O'Brien (UofT, Pharmacology) and P. Wells (SGS chair). Ms. Huan YuThesis Title: Automated Definition of Radiation Targets Using Textural Characteristics of Co-registered PET/CT Images The following will comprise her examining committee: Drs. C. Caldwell (Supervisor), G. Czarnota (Supervisory Committee Member) A. Celler (University of British Columbia), A. Martel (Supervisory Committee Member), A. Mihailidis (Occupational Science & Occupational Therapy), G. Pang (MBP) J. Rowlands (Co-supervisor) and J. Henderson (SGS Chair). Mr. Adam DurbinThesis Title: Studies on Signal Transduction Mechanisms in Rhabdomyosarcoma The following will comprise his examining committee: Drs. D. Barber (Supervisory Committee Member), S. Dunn ( University of British Columbia), D. Malkin (Supervisor), J. McGlade (MBP), M. Ohh (LMP, UofT), B. Raught (MBP), and SGS Chair, (TBA). Mr. Raffi KarshafianThesis Title: On the Permeabilisation and Disruption of Cell Membranes by Ultrasound and Microbubbles The following will comprise his examining committee: Drs. P. Burns (Supervisor), R. Cobbold (IBBME), L. Crum (University of Washington), J. Gariepy (MBP) D. Hill (Supervisory Committee Member), K. Hynynen (Supervisory Committee Member) and SGS Chair (TBA). Ms. Jenny ChanThesis Title: Structure-function relationships in the inositol 1, 4, 5-trisphosphate receptor The following will comprise her examining committee: Drs. A. Chakrabartty (MBP), S.R.W. Chen (University of Calgary), M. Ikura (Supervisor), D. MacLennan (Supervisory Committee Member), R. Reithmeier (Dept of Biochemistry), D. Rose (Supervisory Committee Member), and A. Lazarus (SGS Chair ). Ms. Elizabeth TaiThesis Title: Characterization of the E3 Ubiqutin Ligase Pirh2 The following will comprise her examining committee: Drs. C. Arrowsmith (Supervisory Committee member), S. Benchimol (Supervisor), W.S. El-Deiry (University of Pennsylvania), R. Hakem (Supervisory Committee member), M. Ohh (Laboratory Medicine), L. Penn (Supervisory Committee member), A. Schimmer (MBP member), and J. Dostrovsky (SGS Chair). Ms. Jinzi ZhengThesis Title: Development and Characterization of a Liposome Imaging Agent The following will comprise her examining committee: Drs. D. Jaffray (Supervisor), M. Rauth (MBP), V. Torchilin (Northeastern University), R. Reilly (Pharmaceutical Sciences, UofT), C. Allen (Supervisory committee member), M. Henkelman (Supervisory committee member), C. Menard (Supervisory committee member), and B. Schneider (SGS Chair). Ms. Terri RichmondThesis Title: Negative Regulatory Mechanisms Underlying EPO Receptor Signaling and Erythropoiesis The following will comprise her examining committee: Drs. D. Barber (Supervisor), J. McGlade (Supervisory Committee member), M. Ohh (Supervisory Committee Member), B. Raught (MBP), D. Rotin (Biochemistry), E.R. Stanley (Albert Einstein College of Medicine), and J. Rini (SGS Chair). Mr. Maciej (Matthew) WronskiThesis Title: Development of a Flat Panel Detector with Avalanche Gain for Interventional Radiology The following will comprise his examining committee: Drs. J. Rowlands (Supervisor), M. Rauth (Supervisory Committee member), D. Plewes (Supervisory Committee member), Z-H. Lu (Material Sci. & Eng., UofT), D. Holdsworth (Robarts Research Institute), B. Wilson (MBP), and R. Jankov (SGS Chair). Mr. Stephen Huang-Ting ChenThesis Title: Identification and Characterization of potential modulators of Tek/Tie-2 signaling The following will comprise his examining committee: Drs. D. Barber (MBP), Y. Ben-David (Supervisory Committee Member), D. Dumont (Supervisor), A. Seth (LMP), M. Tremblay (McGill University), J. Woodgett (Supervisory Committee member) and SGS Chair (TBA) Ms. Elena BogdanovicThesis Title: Regulation of Tie2 by Ang-1 and Ang-2 in endothelial cells The following will comprise her examining committee: Drs. J. Booth (Supervisory Committee Member), B. Coomber (University of Guelph), D. Dumont (Supervisor) J. McGlade (Supervisory Committee Member), J. Rast (MBP), B. Yang (LMP) and TBA (SGS Chair). Mr. Rob LaisterThesis Title: Structural and Functional analysis of the Mus81/Eme1 endonuclease The following will comprise his examining committee: Drs. C. Arrowsmith (Supervisor), K. Borden (Université de Montreal), R. Hakem (MBP), L. Kay (Supervisory Committee member), M. Minden (Supervisory Committee Member), F. Sicheri (Medical Genetics, UofT) and J. Wells (SGS Chair). Ms. Carol CheungThesis Title: The role of BERP in Mammalian Systems The following will comprise her examining committee: Drs. S. Benchimol (Supervisory Committee member), J. Henderson (Pharmaceutical Sciences), A. Levine (Institute for Advance Study, School of Natural Sciences), T. Mak (Supervisor), M. Tsao (MBP), J. Woodgett (Supervisory Committee member) and SGS Chair (TBA). Ms. Celina SturkThesis Title: The TIE2 RTK: Regulation and Downstream Signaling The following will comprise her examining committee: Drs. Y. Ben-David (MBP), D. Dumont (Supervisor) J. Filmus (Supervisory Committee Member), P. Greer (Queen's University), M. Hough (LMP), J. McGlade (Supervisory Committee Member), C. Whyne (SGS Chair). Mr. Simon SmuklerThesis Title: Stem Cells of the Neural and Pancreatic Lineages The following will comprise his examining committee: Drs. D. van der Kooy (Supervisor), G. Keller (MBP), M. Rudnicki (Ottawa Health Research Institute, University of Ottawa), V. Tropepe (Cell & Systems Bio, UofT), N. Iscove (Supervisory committee member), F. Miller (Supervisory committee member), and S. Asa (SGS Chair). Mr. Chris FolkinsThesis Title: Interactions of cancer stem cells and tumour vasculature The following will comprise his examining committee: Drs. D. Dumont (Supervisory Committee Member), P. Dirks (LMP), L. Ellis (University of Texas/M.D. Anderson Cancer Centre), B. Kerbel (Supervisor), D. Pillai (SGS Chair) M. Puri (MBP) and M. Rauth. Ms. Ekaterina KuznetsovaThesis Title: Activity-based functional annotation of unknown proteins: HAD-like hydrolases from E. coli and S. cerevisiae The following will comprise her examining committee: Drs. A. Edwards (Supervisor), A. Chakrabartty (MBP), J. Gerlt (University of Illinois at Urbana-Champaign), R. Mahadevan (Chem Eng), E. Pai (Supervisory committee member), G. Prive (Supervisory committee member), D. Zamble (Supervisory Committee member), and D.E.C. Cole (SGS Chair). Mr. John BrackenThesis Title: Multimodality imaging for aortic valve replacement The following will comprise his examining committee: Drs. P. Burns (Supervisory Committee Member), Drangova (University of Western Ontario), K. Dunbar (SGS Chair), M. Joy (IBBME), D. Plewes, J. Rowlands (Supervisor) and G. Wright (Supervisory Committee Member). Ms. Roxana VladThesis Title: Quantitative ultrasound characterization of responses to radiotherapy in vitro and in vivo The following will comprise her examining committee: Drs. P. Burns (Supervisory Committee Member), R. Cobbold (IBBME), G. Czarnota (Supervisor), E. Feleppa (Riverside Research Institute), S. Foster, H. Heerklotz (SGS Chair), M. Kolios (Co-supervisor) and F. Liu (Supervisory Committee Member). Ms. Karla Badger-BrownThesis Title: Investigation of the Role of CBL-B in Leukemogenesis and Migration The following will comprise her examining committee: Drs. D. Barber (Supervisor), J. McGlade, M. Minden (Supervisory Committee member), R. Khokha (Medical Biophysics), S. Egan (Molecular Genetics, UofT), M. Tomasson (Wash Univ Sch of Med), and E. Peter (Nursing, UofT). Mr. Yong-Chen LuThesis Title: Regulation of Toll-like Receptor Signal Transduction Pathways The following will comprise his examining committee: Drs. P. Ohashi (Supervisor), D. Barber (Supervisory Committee member), J. Gommerman (Supervisory Committee member), R. Rottapel (Medical Biophysics), J. Withers (Immunology, UofT), M. Olivier (McGill University), L. Penn (Supervisory Committee member), and SGS Chair (TBA). Mr. Beau StandishThesis Title: Real-Time Vascular Monitoring and Quantification of Photodynamic Therapy via Interstitial Doppler Optical Coherence Tomography The following will comprise his examining committee: Drs. A. Vitkin (Supervisor), P. Burns (Supervisory Committee member), B. Wilson (Supervisory Committee member), M. Rauth (Medical Biophysics), C. Yip (IBBME, UofT), B. Bouma (Harvard Medical School), and SGS Chair (TBA). Mr. Nigel MunceThesis Title: The Potential of Optical Coherence Tomography for Intravascular Imaging of Chronic Total Occlusions The following will comprise his examining committee: Drs. A. Vitkin (Supervisor), G. Wright (Co-Supervisor), B. Wilson (Supervisory Committee member), M. Puri (Medical Biophysics), D. Steinman (Mechanical Engineering/IBBME, UofT), G. Tearney (Harvard Medical School), V. Yang, and SGS Chair (TBA). Ms. Irina MateiThesis Title: The Role of Ataxia-telangiectasia mutated (ATM) Protein in Promoting Normal T Cell Development and Preventing T Cell The following will comprise her examining committee: Drs. J. Danska (Supervisor), C. Guidos (Co-Supervisor), R. Bristow (Supervisory Committee member), J. Squire (Supervisory Committee member), M. Minden (Medical Biophysics), M. Anderson (Immunology, U of T), W. Pear (University of Pennsylvania), and SGS Chair (TBA). Mr. Paul ConstantinouThesis Title: Development and Evaluation of Whole Slide Hyperspectral Confocal Fluorescence and Brightfield Macroscopy The following will comprise his examining committee: Drs. B. Wilson (Supervisor), D. Hedley (Supervisory Committee member), A. Vitkin (Supervisory Committee member), A.E. Dixon, M. Yaffe (Medical Biophysics), W. Chan (IBBME, U of T), Y. DeKoninck (Université de Laval), and D. Pringle (SGS Chair). Mr. Anthony JoshuaThesis Title: Telemere Dysfunction in the Evolution
of Prostatic Carcinogenesis The following will comprise his examining committee: Drs. J. Squire (Supervisor), M. Gauthier (Supervisory Committee Member), I. Tannock (Supervisory Committee Member), S. Done (Medical Biophysics), A. Huang (LMP), S. Mai (Manitoba Institute of Cell Biology), and TBA (SGS Chair). 2008
Mr. Paul BoutrosThesis Title: Molecular Prediction of Patient
Prognosis The following will comprise his examining committee: Drs. L. Penn (Co-Supervisor), I. Jurisica (Co-Supervisor), M-S. Tsao (Supervisory Committee Member), A. Schimmer (Medical Biophysics), J. Parkinson (Medical Genetics), B. Ren (Univ. of California), and TBA (SGS Chair). Mr. Ananth RaviThesis Title: Guidance of
breast cancer therapy using gamma-ray detectors The following will comprise his examining committee: Drs. L. Beaulieu (Laval University), M. Bronskill (Supervisory Committee Member), C. Caldwell (Supervisor), M. Joy (IBBME), G. Pang, J. Pignol (Supervisory Committee Member), J. Rowlands (Co-supervisor) and SGS Chair (TBA). Mr. Johann MicallefThesis Title: MARCKS and IQGAP1 are
Important Mediators of Glioma Cell Invasion Downstream Of Aberrant EGFR Expression The following will comprise his examining committee: Drs. A. Guha (Supervisor), D. Barber (Supervisory Committee Member), R. Khokha (Supervisory Committee Member), R. Del Maestro (McGill University), B. Raught (Medical Biophysics), A.M. Rauth (Supervisory Committee Member), J. Rutka (Laboratory Medicine & Pathobiology, and TBA (SGS Chair). Ms. Angelina StojanovaThesis Title: The Role of the INI1
Co-factor and Cellular Context on Myc-dependent Transformation The following will comprise her examining committee: Drs. L. Penn (Supervisor), R. Bremner (Supervisory Committee Member), V. Stambolic (Supervisory Committee Member), P. Cheung (Medical Biophysics), J. Ellis (Molecular and Medical Genetics), J. A. Biegel (University of Pennsylvania), E. Hodnett (SGS Chair). Mr. Norman AnthopoulosThesis Title: Genetic Studies of P13'KlfkBIGSK-3
Signaling in Drosophila The following will comprise his examining committee: Drs. M. Ikura, A. Manoukian (Supervisor), H. McNeil (Medical Genetics), C. Rushlow (New York University), J. Squire (Supervisory Committee Member), J. Woodgett (Supervisory Committee Member), and A. Bassett (SGS Chair). Mr. Jay Detsky Thesis Title: Cardiac Tissue Characterization
Following Myocardial Infarction Using Magnetic Resonance Imaging The following will comprise his examining committee: Drs. A. Dick (Supervisory Committee Member, non-voting), A. Martel (Supervisory Committee Member), D. Plewes (Medical Biophysics), F. Prato (Univ. of Western Ontario), B. Strauss (LMP, U of T), A. Vitkin (Supervisory Committee Member), and G. Wright (Supervior), and B. Harvey (SGS Chair). Ms. Julie SymesThesis Title: Fas-mediated apoptosis in prostate
cancer: gene therapy and synergism with chemotherapy The following will comprise her examining committee: Drs. D. Hedley (Medical Biophysics), M. Los (University of Manitoba), J. Medin (Supervisor), R. Miller (Supervisory Committee Member), V. Stambolic (Supervisory Committee Member), A. Zlotta (Dept of Surgerg), and T. Inaba (SGS Chair). Mr. Peter StogiosThesis Title: Sequence and Structural Analysis
of the BTB Domain The following will comprise his examining committee: Drs. R. Marmostein (Wistar Institute), G. Privé (Supervisor), D. Rose (Supervisory Committee Member), B. Steipe (Biochemistry), E. Tillier (Medical Biophysics, and R. Kaul (SGS Chair). Mr. Wissam AssailyThesis Title: LPIN: A new p53 regulated gene
induced by DNA damage and glucose withdrawal and its involvement in fatty acid
oxidation. The following will comprise his examining committee: Drs. D. Barber (Supervisory Committee Member), S. Benchimol (Supervisor), R. Bristow (Supervisory Committee Member), M. Irwin (Cell Biology), S. Lee (Harvard Medical School), A. Schimmer (Medical Biophysics), and L. Osborne (SGS Chair). Mr. Samuel RichardThesis Title: Optimization of Imaging Performance
and Conspicuity in Dual-Energy X-Ray Radiography The following will comprise his examining committee: Drs. J. Siewerdsen (Supervisor), M. Yaffe (Supervisory Committee Member), T. Roberts (Supervisory Committee Member), C. A. Mistretta (Univ. of Wisconsin-Madison), A. Vitkin (Medical Biophysics), N. Paul (Medical Imaging), H. Heerklotz (SGS Chair) Mr. Niket ShahThesis Title: Elucidation of the catalytic
mechanism of Golgi alpha-mannosidase II The following will comprise his examining committee: Drs. D. Rose (Supervisor), L. Howell (Supervisory Committee Member), G. Prive (Supervisory Committee Member), H. Schachter (Supervisory Committee Member), D. Bundle (U of Alberta), A. Koch (Medical Biophysics), J. Carver (Molecular Genetics), R. Baker (SGS Chair) Ms. Miriam MossobaThesis Title: Development of immunotherapy
against prostate cancer using lentivirally-transduced dendritic cells expressing
murine erbB2 as a model tumor-associated antigen The following will comprise her examining committee: Drs. J. Medin (Supervisor), D. Barber (Supervisory Committee Member), P. Ohashi (Supervisory Committee Member), J. Thibodeau (University of Montreal), D. Spaner (Medical Biophysics), D. Branch (LMP) and S. Tobe (SGS Chair) Mr. Daniel VoskasThesis Title: Characterization
of the biological roles for Tek/Tie-2 in embryonic development and adult
disease. The following will comprise his examining committee: Drs. I. Aubert (SGS Chair), Y. Ben-David, D. Dumont (Supervisor), S. Hussain (McGill University), M. Johnston (Laboratory Medicine & Pathobiology), and M. Puri (Supervisory Committee Member). Mr. David BatemanThesis Title: Structural and kinetic characterization
of cell surface and internalized Alzheimer amyloid peptides in neuronal cells. The following will comprise his examining committee: Drs. A. Chakrabartty (Supervisor), J. Gariepy (Supervisory Committee Member), J. McLaurin (Supervisory Committee Member), G. Levesque (Univ. of Laval), P. Fraser (Medical Biophysics), F. Keeley (Biochemistry, U of T), and R. Cockerill (SGS Chair) Ms. Subodini PerampalamThesis Title: Cell-Targeted Ribosome-Inactivating
Proteins Derived from Protein Combinatorial Libraries. The following will comprise her examining committee: Drs. J. Gariepy (Supervisor), R. Khokha (Supervisory Committee Member), R. MacKenzie (Institute for Biological Sciences, Ottawa), A. Manoukian (Supervisory Committee Member), D. Rose (Medical Biophysics), J. Shin (Chemistry, U of T) and H. Anderson (SGS Chair). Ms. Rama GrantabThesis Title: Penetration of Anticancer Drugs
in Solid Tumors as a Function of Cellular Adhesion and Packing Density The following will comprise her examining committee: Drs. I. Tannock (Supervisor), M. Moore, R. Kerbel (Supervisory Committee Members), D. Hedley (Medical Biophysics), C. Allen (Pharmacy, U of T), J. Rak (McGill University) and SGS Chair (TBA) Ms. Shobha RamsubirThesis Title: Retrovirus-mediated Gene Therapy for Farber Disease Ms. Luisa Izzi Thesis Title: Novel mechanisms of transcriptional repression
by the paired-like homeodomain transcription factor Goosecoid Ms. Caitlin HammondDate & Time: Tuesday, March 11, 2008, 2:00 p.m. The following will comprise her examining committee: Drs. M. Anderson (Immunology), N. Berinstein (Supervisory Committee Member), S. Gibson (University of Manitoba), M. Minden, D.Spaner (Supervisor) and M. Zhen (SGS Chair). |
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