ProfessorPhD, Jagiellonian University
Sunnybrook Health Sciences Centre
2075 Bayview Avenue, S-Wing, Suite S672
Toronto, Ontario M4N 3M5
Phone: (416) 480-5725
Email Dr. Greg Stanisz
Phone: (416) 480-4293
Email Janet Binding
Quantitative Magnetic Resonance Imaging - Mechanisms of Tissue Contrast
The goal of our studies is to develop magnetic resonance imaging (MRI) methods to improve specificity and sensitivity of non-invasive image methods in characterizing tissue pathology. We use MRI both in animal models of disease and in patients. In particular we use MRI to evaluate tissue microstructure and metabolism in variety of different disorders. Our research interest include, but are not limited to:
- Optimizing MRI methods to predict tumour response to treatment,
- Applying new imaging technology for MRI-Linac and MRI-brachytherapy systems,
- Developing MRI methods to assess radiation dose,
- Testing new multimodal contrast agents for improved specificity of cancer diagnosis,
- Characterizing new models of spinal cord injury and testing new treatments for SCI,
- Understanding the mechanisms of tissue damage in central nervous system,
- Evaluating brain metabolism using magnetic resonance spectroscopy (MRS) in response to microbiotic treatment in animal models of depression.
Our group has an access to following facilities:
- 3 T MRI human systems (GE, Phillips, Siemens),
- 7 T MRI animal scanner (Bruker),
- Animal PET/SPECT/CT system (MILabs),
- Multiphoton in vivo microscope (Olympus)
Our group consists of four students (three PhD and one MSc) three post-doctoral fellows and three research associates (biology and physics).
For further information, please visit homepage http://sunnybrook.ca/team/member.asp?t=13&m=163&page=172
List of Key Publications:Link to Pubmed Publications
Bailey C, Moosvi F, Stanisz GJ. Mapping water exchange rates in rat tumor xenografts using the late-state uptake following bolus injections of contrast agents. Magn Reson Med. 2014;71:1874–87.
Desmond KL, Moosvi F, Stanisz GJ. Mapping of amide, amine and aliphatic peaks in the CEST spectra of murine xenografts at 7T. Magn Reson Med. 2014;71:1841–53.
Portnoy S, Fichtner ND, Dziegielewski C, Stanisz MP, Stanisz GJ. In vitro detection of apoptosis using oscillating and pulsed gradient diffusion magnetic resonance imaging. NMR in Biomed. 2014;27:371–80.
Oakden W and Stanisz GJ. Effects of diffusion on high-resolution quantitative T2 MRI. NMR in Biomed. 2014;27:672–80.
Oakden W, Kwiecien JM, O-Reilly MA, Lake EM, Akens MK, Aubert I, Whyne C, Finkelstein J, Hynynen K, StaniszJ. A non-surgical model of cervical spinal cord injury with focused ultrasound and microbubbles. J Neurosci Methods. 2014;235:92–100.
- Rafal Janik, PhD - “Gut Microbiome and Brain Neurotrasmitters”
- Kayla Sutton, MSc - “Changes in MRI Tissue Parameters due to Ionizing Radiation”
- Rozhin Yousefi, PhD - “Tumor Treatment Response Evaluation: MRI measurements of tumor microstructure and microenvironment”
- Evelyn Lake, PhD - “Imaging functional recovery in stroke”