Assistant ProfessorPh.D., University of Toronto
25 Orde St. 5-1018
Toronto, Ontario M5T-3H7
Phone: 416-586-4800 X 8455
Email Dr. Mira Puri
Cardiovascular and Hematopoietic Development
Research in my laboratory focuses on the cellular and molecular mechanisms that lead to the formation and stability of the cardiovascular and hematopoietic systems in mammals. During development, this process is tightly coordinated, involving the differentiation and interaction of several cell lineages to form the heart, blood vessels and circulating blood cells, and thus is dependent on signals exchanged by these cell types. Our research concentrates on two families of signalling molecules, TIE1 and TIE2 receptor tyrosine kinases, and the TGFb/BMP receptor, Endoglin. These cell surface receptors are expressed in both endothelial and hematopoietic cells in the embryo and the adult. Consistent with this restricted expression patterns, these molecules have been implicated in a number of human disease states involving the unchecked growth or differentiation of vascular and hematopoietic cells. Using the mouse as a model system, we take a genetic approach both in vivo and in embryonic stem cells to define the cellular processes mediated by these pathways in establishment of the hematopoietic stem cell microenvironment, as well as the patterning of both blood and lymphatic circulatory system during embryogenesis and early postnatal life.
List of Key Publications:Link to Pubmed Publications
Endoglin is dispensable for angiogenesis, but required for endocardial cushion formation in the midgestation mouse embryo.
Nomura-Kitabayashi A, Anderson GA, Sleep G, Mena J, Karabegovic A, Karamath S, Letarte M, Puri MC. Dev Biol. 2009 Nov 1;335(1):66-77.