Assistant ProfessorPhD, University of Toronto
Mouse Imaging Centre
Hospital for Sick Children
Toronto Centre for Phenogenomics
25 Orde Street
Toronto, Ontario M5T 3H7
Phone: (647) 837 5828
Fax: (647) 837 5832
Email Dr. Ben Neel
Development of cellular imagingmethods for biomedical research
As success with treating pediatric brain cancers has grown, it has also become clear that there are frequently debilitating side effects to the radiation and chemotherapy treatments that have improved survival. These side effects are known to include neurocognitive and behavioural deficits, but the mechanism by which they develop remains unclear. Dr. Nieman’s lab is characterizing the neuroanatomical consequences of treatment that are associated with side effects and investigating genetic factors that might mitigate them.
It is well recognized that cancers are composed of a diverse group of cells. Advances in cancer diagnoses and treatments must account for this heterogeneity and target the cells most responsible for sustaining or repopulating the cancer. Thus, characterizing the distribution of different cell types and determining their activity remain fundamental parts of cancer research. The ability to do so in three-dimensions, and even non-invasively, would greatly improve our understanding of how cancers progress and how cells — both normal and cancer — respond to treatment. Dr. Nieman’s lab is developing imaging methods to achieve this aim, primarily focusing on magnetic resonance and optical cellular imaging technologies.
List of Key Publications:Link to Pubmed Publications
B. J. Nieman, A. M. Flenniken, S. L. Adamson, R. M. Henkelman, J. G. Sled. Anatomical phenotyping in the brain and skull of a mutant mouse by magnetic resonance imaging and computed tomography. Physiol Genomics 2006; 24:154-162.
B. J. Nieman, J. Bishop, J. Dazai, N. A. Bock, J. P. Lerch, A. Feintuch, X. J. Chen, J. G. Sled, R. M. Henkelman. MR technology for biological studies in mice. NMR Biomed 2007; 20:291-303.
B. J. Nieman, J. P. Lerch, N. A. Bock, X. J. Chen, J. G. Sled, R. M. Henkelman. Mouse behavioral mutants have neuroimaging abnormalities. Hum Brain Mapp 2007; 28:567-575.
B. J. Nieman, K. U. Szulc, D. H. Turnbull. Three-dimensional, in vivo MRI with self-gating and image coregistration in the mouse. Magn Reson Med 2009; 61(5):1148-1157.
C. A. Berrios-Otero, Y. Z. Wadghiri B. J. Nieman, A. L. Joyner, D. H. Turnbull. Three-dimensional micro-MRI analysis of cerebral artery development in mouse embryos. Magn. Reson. Med 2009; 62(6):1431-1439.
B. J. Nieman, J. Y. Shyu, J. J. Rodriguez, A. D. Garcia, A. L. Joyner, D. H. Turnbull. In vivo MRI of neural cell migration dynamics in the mouse brain. NeuroImage 2010; 50:456-464.
- Marc Carias
- Elizabeth de Guzman