Associate ProfessorPhD, University of Toronto
Sunnybrook Health Sciences Centre
2075 Bayview Avenue, Room A453
Toronto, Ontario M4N 3M5
Phone: (416) 480-6100 x7277
Fax: (416) 480-5775
Email Dr. Bradley MacIntosh
At A Glance:
I work closely with Clinician Scientist in fields of neurology and psychiatry and use magnetic resonance imaging to study the human brain. My lab is using neuroimaging measurements as outcome measures in aerobic exercise trials that are on going. In addition, I work on developing new forms of physiological images, such as measuring cardiac-induced brain pulsatility.
Bradley MacIntosh is a Scientist at Sunnybrook Research Institute in the Brain Sciences research program & Physical Sciences platform, and a core member of the Heart and Stroke Foundation Canadian Partnership for Stroke Recovery. Brad holds an academic post as an Assistant Professor in the Department of Medical Biophysics at the University of Toronto, which is also where he completed his PhD in 2006. His MSc was at the Robarts Research Institute at Western University, supervised by Ravi Menon. After completing his postdoctoral fellowship at the University of Oxford’s Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB), under the supervision of Professor Peter Jezzard, Brad returned to Toronto to take up his current post at the Sunnybrook Research Institute.
My research has focused on vascular and functional neuroimaging techniques that are non-invasive and conducive to clinical translation in human studies. The major focus is on perfusion techniques such as arterial spin labeling to visualize and quantify the cerebral blood flow level in the brain. My lab uses perfusion and hemodynamic techniques to understand aging, stroke recovery and neurodegeneration and identify how aerobic exercise can be used to maintain and recovery brain health.
- Zahra Shirzadi
- Sarah Atwi
- Athena Theyers
List of Key Publications:
Measuring the effects of remifentanil on cerebral blood flow and arterial arrival time using 3D GRASE MRI with pulsed arterial spin labelling. MacIntosh BJ, Pattinson KT, Gallichan D, Ahmad I, Miller KL, Feinberg DA, Wise RG, Jezzard P. J Cereb Blood Flow Metab. 2008 Aug;28(8):1514-22. doi: 10.1038/jcbfm.2008.46.
Cardiopulmonary fitness correlates with regional cerebral grey matter perfusion and density in men with coronary artery disease. MacIntosh BJ, Swardfager W, Crane DE, Ranepura N, Saleem M, Oh PI, Stefanovic B, Herrmann N, Lanctôt KL. PLoS One. 2014 Mar 12;9(3):e91251. doi: 10.1371/journal.pone.0091251.
Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia. Alsop DC, Detre JA, Golay X, Günther M, Hendrikse J, Hernandez-Garcia L, Lu H, MacIntosh BJ, Parkes LM, Smits M, van Osch MJ, Wang DJ, Wong EC, Zaharchuk G. Magn Reson Med. 2015 Jan;73(1):102-16. doi: 10.1002/mrm.25197.
Physiological fluctuations in white matter are increased in Alzheimer's disease and correlate with neuroimaging and cognitive biomarkers. Makedonov I, Chen JJ, Masellis M, MacIntosh BJ. Neurobiol Aging. 2016 Jan;37:12-8. doi: 10.1016/j.neurobiolaging.2015.09.010.