Genome variation and Cancer
Dr. Hudson's laboratory at OICR is involved in the study of genome variation that affects cancer predisposition, progression, and response to therapy. His main project focuses on the genetic architecture of loci associated with risk to colorectal cancer.
Selected References:
Link to Pubmed Publications-
Zanke BW, Greenwood CMT, Rangrej J, Kustra R, Tenesa A, Farrington SM, Prendergast J, Olschwang S, Chiang T, Crowdy E, Ferretti V, Laflamme P, Sundararajan S, Roumy S, Olivier JF, Robidoux F, Sladek R, Montpetit A, Campbell P, Bezieau S, O’Shea AM, Zogopoulos G, Cotterchio M, Newcomb P, McLaughlin J, Younghusband B, Green R, Green J, Porteous M EM, Campbell H, Blanche H, Sahbatou M, Tubacher E, Bonaiti-Pellié C, Buecher B, Riboli E, Kury S, Chanock SJ, Potter J, Thomas G, Gallinger S, Hudson TJ, Dunlop MG. A Colorectal Cancer Susceptibility Locus on Chromosome 8q24 Identified by a Genome-Wide Association Scan. Nature Genetics. 2007; 39(8): 989-994.
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International HapMap Consortium, (TJ Hudson is Project Leader of the Canadian Group). A Haplotype Map of the Human Genome. Nature. 2005; 437:1299-1320.
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Pastinen T, Hudson TJ. Cis-Acting Regulatory Variation in the Human Genome. Science. 2004; 306: 647-650.
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Daly MJ, Rioux JD, Schaffner SF, Hudson TJ, Lander ES. High-resolution haplotype structure in the human genome. Nature Genetics. 2001; 29: 229-232.
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Hudson TJ, Stein L, Gerety S, Ma J, Castle A, Silva J, Slonim D, Baptista R, Rosenberg C, Reeve-Daly MP, Rozen S, Hui L, Hu X, Xu S-H, Wu X, Vestergaard C, Wilson K, Bay J, Colbert A, Maitra S, Ganiatsis S, Evans C, Ingalls K, Nahf R, Kruglyak L, Anderson M, Collymore A, Courtney D, Devine R, Horton L, Kouyoumjian V, Nguyen H, Renaud M, Tam J, Ye WJ, Zemsteva I, O'Connor T, Faure S, Fizames C, Goodman N, Weissenbach J, Hawkins T, Foote S, Page DC, Lander ES. An STS-based map of the human genome. Science. 1995; 270: 1945-1954.
