Role of dietary factors and susceptibility genes in cancer development
One objective of my research program is to identify molecular targets of dietary factors involved in breast and colon cancer development. Current research focuses on HMG-CoA reductase and the mevalonate pathway, cyclooxygenase-2, fatty acid synthase, and insulin, IGF-I, and other obesity-related factors. A second objective is to understand the genetic basis for the differences in susceptibility of rat strains to breast and liver cancer induction.
Previous Graduate Students:
- Geoffrey A. Wood, Assistant Professor of Veterinary Pathology, University of Guelph
- James E. Korkola, Research Associate, Memorial Sloan-Kettering Cancer Center, New York, NY
- Shi-Jiang Lu, Adjunct Associate Professor, Northwestern University, Chicago, IL
- Valentia Lee-Brotherton, Scientific Consultant, CanTox Inc. Mississauga
Selected References:
Link to Pubmed Publications-
Ealey, K.N., Xuan, W., Lu, S. and Archer, M.C. Colon carcinogenesis in liver-specific IGF-I-deficient (LID) mice. Int. J. Cancer, 122, 472-476, 2008.
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Ealey, K.N., Lu, S., Lau, D.S.Y. and Archer, M.C. Reduced susceptibility of muscle-specific insulin receptor knockout (MIRKO) mice to colon carcinogenesis. Am. J. Physiol. (Gastrointest. Liver Physiol.) 294, G679-G686, 2008.
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Ealey, K.N, Lu, S., and Archer, M.C. Development of aberrant crypt foci in the colons of ob/ob and db/db mice: evidence that leptin in not a promoter. Molecular Carcinogenesis, 47, 667-677, 2008.
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Xuan, W., Li, Y-J., Ben-David, Y. and Archer, M.C. IL-24 induces expression of β4 integrin and suppresses anchorage-independent growth of rat mammary tumor cells. Mol. Cancer Res., 7, 433-442, 2009.
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Lau, D. S. Y. and Archer, M.C. Fatty acid synthase is over-expressed in large aberrant crypt foci in rats treated with azoxymethane. Int. J. Cancer, 124, 2750-2753, 2009.
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Ealey, K.N. and Archer, M.C. Elevated circulating adiponectin in adiponectin transgenic mice is not associated with reduced susceptibility to colon carcinogenesis. Int. J. Cancer, 124, 2226-2230, 2009.
