MBP 1015Y Graduate Student Seminars

*Note: Please provide your seminar titles as soon as possible to Daphne Sears (daphne.sears@utoronto.ca). Titles need to be available at least 6 weeks prior to your seminar date so it is desirable to have them available at the start of the seminar series.

The primary goals of the MBP Student Seminar Series (course MBP1015Y) are to provide the student with practical experience and guidance for clear and concise oral communication of research results to an audience of educated non-specialists. This is an essential skill for anyone seeking a career in scientific research and beyond.  This emphasis differs from that of a group meeting or conference style talk given to an audience of specialists; here, the student presents to a diverse interdisciplinary group of peers, so familiarity with the field, its details, its specialized terms and abbreviations CANNOT be assumed.  This may be more analogous to a job talks or a teaching situation, where getting the essential points across and engaging the audience are key.  In this year's seminars, all speakers should expect a particularly broad audience with the mixture and uptown and downtown physics and biology talks.

A secondary important goal of the series is to give each student a broad knowledge of all aspects of research undertaken in MBP. At any oral examination and committee meeting, a student can be asked to demonstrate some familiarity with research in the Department not related to his/her own area. Attendance at the Student Seminars is the principal means of acquiring this familiarity.

An engaged, interested, interactive audience is essential to the success of MBP1015Y, hence ask questions. We will note attendance at both sites through the seminar evaluation forms each attending student fills out.  Non-participating students can face marks deduction at the end of the academic year.

It is very important to get regular attendance from a significant number of faculty members, to ensure consistent and fair evaluations. Please attend and interact with colleagues whenever possible (ideally every week). There is compelling evidence that the mark a student receives in this course is correlated with the attendance record of the supervisor.  So please lead by example!  

Following the seminars, the faculty members remain in the seminar room for a brief evaluation period that provides direct feedback to the presenters.  The discussion is led by the course coordinators, Drs. Alex Vitkin and Michael Hoffman for the downtown location and Dr. Brad MacIntosh at Sunnybrook.  2nd year MSc and PhD students will receive a mark providing the basis for the grade on their transcript. As mentioned above, good faculty participation, comprising in and out of stream members, is important to ensure a fair and robust evaluation process.

For information on the preparation of seminars, please consult the guidelines posted on the MBP website: Seminar Guidelines

Miscellaneous points of note:

  • Both auditoria are available half an hour before the start of the seminar onwards to provide ample time for presenters to test computer equipment and presentation material prior to going live.
  • First year MSc students will give a practice seminar towards the end of the winter term; the schedule for these will be posted in early 2017.  Also a training session will be announced at that time. 
  • Post-docs, technicians, clinical collaborators and other interested staff are welcome to take part
  • It is extremely rude and disruptive for any attendee to enter late and/or leave early. Please remain for the entire session (two to three speakers) if possible

Seminar Guidelines

Abstract Submission:
Concise abstracts (~ 250 words) should be provided similar to an abstract for a poster at a scientific conference. The name of the supervisor should be included on the abstract. All speakers should Email their abstracts to Daphne Sears (daphne.sears@utoronto.ca) on the Friday before your seminar. All students are asked to use the templates below when preparing their abstracts. Abstracts should not be over 1 page long.

***Please note that abstracts received after the deadline will NOT be circulated***

Abstract Template - Sunnybrook

Abstract Template - Downtown

Shuttle Bus Schedule

Evaluation form to be used by faculty

Evaluation form to be used by students


September | October | November | December | January | February | March | April | May | June|

Sunnybrook: Tuesdays at 3:00 PM. 
Sunnybrook, 2075 Bayview Avenue, Rm M6-502 (Breast Clinic Theatre)

Downtown: Wednesdays at 4:00 PM. 
Princess Margaret Cancer Centre Auditorium, 610 University Avenue, Room 6-604

Schedule - 2016-17

Fall 2016





Wed. Sept. 28, 2016
Princess Margaret, Auditorium

 Dr. Alex Vitkin - Seminar course basics: the what and the how

Dr. John Rubinstein - How to give a scientific talk

Tue. October 4, 2016

**M6-502 Lecture Theatre, (M-wing)

3 to 3:30PM
"A Manifesto for a New Era of Canadian Science”
 -- Dr. Jim Woodgett, Professor of Medical Biophysics, University of Toronto
   Director of Research for the Lunenfeld-Tanenbaum Research Institute

3:40 to 4:00PM
“How to give a great MBP student seminar: the Do’s and Do not’s" 
 -- Dr. Brad MacIntosh, MBP Uptown Seminar Series Course Coordinator

Wed. October 05

Gribble, Adam


Rapid polarized light imaging for breast cancer analysis

Mehrabi, Pedram


Functional dynamic studies of an enzyme, Fluoroacetate dehalogenase

Tue. October 11

Sollazzo, Peter


Targeting differentiation pathways in Neuroblastoma

Stewart, Erin


Characterizing residual erlotinib-tolerant population using EGFR-mutated NSCLC Primary Derived Xenografts: The last holdouts

Wed. October 12

Ng, Deborah


Characterizing the Human Ubiquitin Conjugating Enzymes

Portnoy, Sharon

Sled & Macgowan

Advanced MRI Methods for Analysing the Fetal Circulation.

Tue. October 18

Geraghty, Benjamin


The Big Data Rush: An Introduction to Data Science

Smith, Tracy


Characterization of Tie2 signalling during acute inflammation

Wed. October 19

Fang, Zhenhao


Inhibition of KRAS signaling by a novel mechanism of action: stabilizing membrane-dependent occlusion of the effector-binding site

Li, Constance


Pan-Cancer Analysis of Sex Differences in Somatic Mutation Profiles

Tue. October 25

Prodeus, Aaron


Getting a closer look at VISTA;  a new immune checkpoint protein regulator coming up at the horizon.

Demidov, Valentin


Development of optical coherence tomography platform for imaging and quantification of early radiobiological responses in irradiated tissues.

Wed. October 26

Bhat, Mamatha


Identification of Prognostic Gene Signatures in Hepatocellular Carcinoma

Galant, Natalie


Monoclonal antibodies specifically targeting amyloidogenic forms of transthyretin (TTR) with potential to treat TTR-related cardiomyopathy and polyneuropathy

Tue. November 01

Doodnauth, Sasha


Tuning immune responses in Atherosclerotic Progression

Fernandes, Darren


Spatial Gene Expression Analysis of Neuroanatomical Differences in Mouse Models

Wed. November 02

Lee, Jeehoon


Modeling the early diversification of atrial and ventricular lineages using human pluripotent stem cells (hPSCs)

Fernandez, Nestor


The role of retinoic acid signaling in development of the human embryonic hematopoietic system

Tue. November 08

Walter, Jane


Evaluation of a Portable Optical Spectroscopy Device for Breast Cancer Risk Assessment

Yee, Yohan


Brain volume covariance is associated with structural connectivity and gene co-expression

Wed. November 09

Lourenco, Corey


Modelling MYC-dependent transformation of triple-negative breast cancer in vivo.

Rajakumar, Sujeetha


RANK-RANKL Mediated Bone Destruction in B-Cell Acute Lymphoblastic Leukemia (ALL)

Tue. November 15

McElcheran, Clare


Parallel RF Transmit for the Reduction of Heating in DBS Leads

Oldham, Robyn


Development and testing of novel chimeric antigen receptors for cancer immunotherapy

Wed. November 16

Barghout, Samir


UBA1 as a novel therapeutic target in acute myeloid leukemia

Atkins, Michael


Modelling human embryonic hematopoietic development with pluripotent stem cells

Tue. November 22

Steinman, Joseph


The Effect of Traumatic Brain Injury on Vascular Structure and Function in the Mouse Brain

Hickman, Ashley


Identifying Novel Regulators of Myc Stability

Wed. November 23

Fox, Natalie


Prognosis and Genomic Subtypes in Prostate Cancer

Botham, Aaron


Mapping the Interactome of Mitochondrial Proteases in the Intermembrane Space using Proximity-Dependent Biotin Labeling to Identify Novel Functions

Tue. November 29

Welch, Mattea


Radiomic Techniques

Schuh, Nicholas


The bacterial microbiota influences resistance to infection in a simple animal model of colonization and immunity

Wed. November 30

Gottwald, Jennifer


Quantitative PET for Hypoxia Imaging

Oldfield, Leslie


Lynch Super Panel: An integrative panel to detect Lynch Syndrome

Tue. December 06

Tharmapalan, Pirashaanthy


The Progesterone-Calcitonin Pathway in the Adult Mammary Gland and Breast Cancer

Zanette, Brandon


Functional MRI of Radiation-Induced Lung Injury with Hyperpolarized Xenon-129

Wed. December 07

Kao, Ingrid


Improving Immunotherapy through epigenetic modulation in triple-negative breast cancer

Pellow, Carly

Zheng & Goertz

Ultrasound-triggered conversion of porphyrin microbubbles to nanobubbles: Exploring cavitation activity beyond the vasculature

Tue. December 13

Krahn, Philippa


Magnetic Resonance and Electrophysiological Characterization of Acute Cardiac Ablation Lesions

Kumar, Megha


Exploring the Therapeutic Potential of Modulating GSK3 Activity in Cancer

Wed. December 14

Rostami, Ariana


Assessing response to radiotherapy in HNSCC through circulating tumour DNA detection.

Lambie, Meghan


Pre-clinical validation of pharmaceutical selection to enhance synergy with radiation

Tue. December 20

Hyvarinen, Mikko


Computer Simulations for Applications of Magnetic Resonance Imaging Guided Focused Ultrasound Surgery (MRIgFUS) for Treatments of Uterine Fibroids

Lee, Casey


Investigating the Correlation between Hyperpolarized 13C MRI and Ex Vivo NMR Analysis on Lactate Metabolism

Winter 2017

Tue. January 03



Hyperpolarized Xenon MRI of Brain Oxygenation

Motmaen Dadgar, Maryam

Hynynen Ultrasound phased-array transducer design for the treatment of deep vein thrombosis

Wed. January 04

Chen, Lucy


Evolutionary models of endothelial heterogeneity: A role for epigenetic pathways in mitotic selection

Huang, Tonny


Functional proteomics reveal novel functions of FBXW7

Tue. January 10

Pemberton, James


Understanding the role of Puma in neuronal maturation and death

Theyers, Athena


Validating BOLD fMRI Assessment of Cardiac Pulsatility in the Brain Using Exercise-Induced Hypotension

Wed. January 11

Madani Tonekaboni, Ali


Development of computational pipelines for optimization of drug development and patient matching

Patel, Parasvi


Role of RNF168 in breast cancer associated with BRCA1 mutations

Tue. January 17

Ragot, Don


Echo-time optimization in spin echo fMRI using hypercapnic manipulation

van Leeuwen, Jenna


Targeting the metabolic mevalonate pathway with statins as anti-breast cancer agents

Wed. January 18

Richards, Laura


Single-cell analysis of subclonal heterogeneity in primary glioblastoma

Wang, Nina


Profiling Genomic Complexity and Reducing Technical Artifacts using Molecular Barcoding

Tue. January 24

Klein, Jonathan

Czarnota/ Stanisz

In Vivo Measurements of Cancer Using CEST MRI

Goolaub, Datta


3D imaging of fetal blood flow using MRI

Wed. January 25

Lou, Jenny


The Use of Porphysomes to Enhance Adoptive Cell Therapy

Yin Liao, May


ATM-mediated phosphorylation of nuclear PTEN as a function of genome maintenance

Tue. January 31

Adams, Conner


In-Vivo Imaging of Longterm Cerebrovascular Dysfunction Following Serial Mild Traumatic Brain Injury

Zajac, Zachary


Using Nanoscale Phase-Change Droplets for Indicator Dilution Measurements of Flow

Wed. February 01

Zhou, Stanley


Investigating the function of noncoding single-nucleotide variants in localized, intermediate-risk prostate cancer

Burgener, Justin


 Development of Epigenetic Biomarkers from Circulating Tumour DNA for Oral Squamous Cell Carcinoma

Tue. February 07

Forward, Sarah


 Novel flexible polarimetric probe for enhanced cystoscopy

Morgado, Felipe


The Effects of T1 Signal Decay on Multiple Breath Washout Imaging using Hyperpolarized Gas MRI

Wed. February 08

Bhandari, Vinayak


The Clinico-Genomics of Tumour Hypoxia

Guo, Hui


Structure of an Active ATP Synthase

Tue. February 14

Chiang, Sylvester


Motion Corruption Detection in Breast MRI

Zhang, Ji


Characterizing Oxygen Consumption and Hypoxia Tolerance in Pancreatic Ductal Adenocarcinoma

Wed. February 15

Chu, Kenneth Lerch

Utilizing multi-shell diffusion-weight MRI to study mouse models of neurodevelopmental disorders

Dobri, Simon Ross The role of GABA in neural oscillations underlying perceptual binding
Karimzadeh Reghbati, Mehran Hoffman Virtual ChIP-seq: predicting transcription factor binding by learning from modulatory effects of gene expression
Tue. February 21 Assimopoulos, Stephania Sled

Advanced MRI and Ultrasound methods for assessment of placental dysfunction and fetal distress 

Coles, Brandon Wright

Increasing the RF Safety of Cardiovascular Interventional Devices during MRI using Parallel RF Transmission

Tue. February 28 Fletcher, Stecia O'Reilly Multifrequency Focused Ultrasound for Blood-Spinal Cord Barrier Opening
Gibson, Christopher DaCosta Clinical translation of a new handheld fluorescence imaging device for tumour margin assessment during breast conserving surgery
Wed. March 1 Grant, Benjamin Ikura

Structural studies of Ras regulation by nuclear magnetic resonance (NMR) spectroscopy

Hawley, James Lupien Epigenomic instability in triple negative breast cancer
Houlahan, Kathleen Boutros

Interplay between germline genetics and somatic mutation profiles in prostate cancer

Tue. March 7 Mouraviev, Andrei Martel

Automated Segmentation and Characterization of Brain Metastases to Predict Response Following Stereotactic RadioSurgery

Nguyen, Dang Andrews

Investigating pro-apoptotic mechanism of Bim in PD-L1 induced T cell death: an in vitro step

Wed. March 8 Mahendralingam, Mathepan Khokha Exploiting the metabolic dependencies of mammary stem and progenitor cells

Structural and functional elucidation of the PRDM protein family

Ivanochko, Danton
Tue. March 14 Oglesby, Ryan Stanisz CEST MRI: Phantom Investigation of the Serotonin Pathway
Riberdy, Vlora Santyr MRI of Pluripotent Stem Cell-Derived Alveolar-Like Macrophages for Treatment of Chronic Lung Diseases
Wed. March 15 Kelly, Jacalyn Tabori

Investigating a functional assay and single-cell hypermutation detection for reliably detecting Biallelic Mismatch Repair Deficiency Syndrome

Nguyen, Francis Hoffman

Assessing epigenomic heterogeneity from single cell ATAC-Seq and RNA-Seq

Law, Jacqueline Liu, F-F An Orthotopic CRISPR Screen for Determinants of Head and Neck Cancer Metastasis
Tue. March 21 Seth, Nikhil Martel

Automated Detection of DCIS in Whole Slide Images

Wed. March 22 Isaev, Karin Reimand

Identifying lncRNA Regulatory Networks in Cancer

Ladumor, Yagnesh Irwin

Investigating calcipotriol as a novel therapeutic for metastatic Neuroblastoma

Poon, Stephanie Ailles

Characterizing the role of Carcinoma-associated fibroblasts in Ovarian Cancer tumour cell invasion

Tue. March 28 Toma, Jonathan Wright  
Wei, Lucy Burns

Direct measurement of Blood Flow Reflections by Ultrasound

Wed. March 29 Psarianos, Pamela Liu, F-F

Targeting Metabolic Epigenetic Alterations to Reverse Radiation Fibrosis

Salcedo, Adriana Boutros

Impact of RB1 genotype on the mutational landscape and evolution of retinoblastoma

Samuel, Timothy DaCosta

Improving our understanding of the in vivo effects of stereotactic body radiation therapy (SBRT) on the perivascular microenvironment of pancreatic tumors.

Tue. April 4 Xu, Rui O'Reilly Optimizing Ultrasound Transducer Design for Spinal Therapy
Geady, Caryn Jaffray/Vitkin

Combining Physiological and Imaging Biomarkers for Targeted Cancer Therapy

Wed. April 5
Su, Peiran He

Functional genomic screening with lung cancer patient-derived xenograft models

Walton, Joseph Ailles

Targeting Epigenetic Regulation in Clear Cell Renal Cell Carcinoma

Tue. April 11 Zhao, Xiaoxiao Goertz

Investigating ultrasound mediated vascular disruption in tumours

Yang, Jing Demore

Array-based Dual Frequency Ultrasound Angiography

Wed. April 12 Yang, Donghe Keller Molecular characterization of the human ventricular cardiomyocyte lineage
Chen, Sujun He

Functional characterization of circular RNA in cancer development and progression

Othman, Kamal   Identifying signaling pathways associated with the misregulation of Numb isoform expression in cancer